Ido Braslavsky, Associate Professor
Department of Physics and Astronomy
Clippinger 251B, Ohio University
Athens ,Ohio, 45701

Braslavs@ohio.edu
Tel: 740-597-3011
Lab: 740-597-1389

Academic Degrees

1998 - Ph.D. in Physics, Technion, Haifa, Israel.
''Imaging of The Temperature Fields Around a Dendritic Crystal''
under the supervision of Prof. Steve. G. Lipson
1992 - B.A. in Physics, summa cum laude, Technion,  Haifa, Israel.
 

Positions

September 2009 - Current     Associate Professor, Department of Physics and Astronomy, Ohio University, Athens, OH
August 2003- August 2009,   Assistant Professor, Department of Physics and Astronomy, Ohio University, Athens, OH

2000-2003, Postdoc at Caltech, Pasadena, California.
Applied Physics, Prof. Steve Quake Group. In collaboration with Prof. Henry Lester, Biology, Caltech.

1998-1999 Postdoc at the Weizmann Institute of Science, Rehovot, Israel.
Department of Physics of Complex Systems Prof. Joel Stavans Group

Visiting Scientist 

Dec 2007,   Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
July 2004,   Department of Materials & Interfaces, Weizmann Institute of Science, Rehovot, Israel

Consulting

2004-2007  Helicos BioSciences, on Single molecule DNA sequencing techniques.
                     

Membership:
BNNT - Ohio University - Biomimetic  Nanoscience and Nano-Technology
NQPI - Nanoscale and Quantum Phenomena Institute
CMSS - Condense Matter and Surface Science
QBI - Quantitative Biology Institute

Current projects :

Investigation of Ice Binding Proteins by Fluorescence Microscopy and Microfluidic Devices
DNA Sequencing at the single molecule level
DNA Oxidation at the single molecule level

News and cover articles

PNAS 2010 Superheating: Ohio University,  ScienceDaily,  PhysOrg

NQPI news letter, Fall 2009, Team studies inner workings of anti-freeze proteins, by Emily Hubbell

BBC: Sub-zero proteins transform dessert, by Victoria Gill,  Aug 2009

Cold Case : Office of Research Communications, Ohio University, May 2009

EMBO reports 9, 9, 838–840 (2008) Philip Hunter , Harnessing Nature's wisdom. Turning to Nature for inspiration and avoiding her follies,

In sequence, Volume 2 - Number 15 | April 8, 2008 : Helicos Publishes M13 Genome Re-Sequencing Data , related article

Physics Today, May 2007 ,    Feb 2008 APS News: "Physics News in 2007"     Related article

Perspectives: Research, Scholarship, and Creative Activity at Ohio University: Fending Off Freeze,  Proteins take a bite out of frost

APS2007: Scientific American ,  Physics update , ScienceDaily,  Ohio University Press release

Ohio University NanoSpintronics and Nanomagnetics web site: "Brain Freeze", by Anita Martin

APS 2006, Virtual pressroom,  title: "Fluorescence microscopy studies of the antifreeze proteins"

Physics News Update 2003   Related article

Publications

"Superheating of ice crystals in antifreeze protein solutions", Yeliz Celik, Laurie A. Graham, Yee-Foong Mok, Maya Bar, Peter L. Davies, and Ido Braslavsky, PNAS, Early Edition March 9, 2010.  PDF,  Supporting information

"Structural basis for the superior activity of the large isoform of snow flea antifreeze protein", Mok YF, Lin FH, Graham LA, Celik Y, Braslavsky I, Davies PL., Biochemistry,  2010.

"Caught in the act: the lifetime of synaptic intermediates during the search for homology on DNA", Adam Mani, Ido Braslavsky, Rinat Arbel-Goren, and Joel Stavans, Nucleic Acids Research, Published  Dec 30, 2009, Advance Access

"Universality of Persistence Exponents in Two–dimensional Ostwald Ripening", Jordi Soriano, Ido Braslavsky, Di Xu, Oleg Krichevsky and Joel Stavans, PRL, 2009, 103(22)226101.

"Direct visualization of spruce budworm antifreeze protein interacting with an ice crystal: basal plane affinity confers hyperactivity"
Natalya Pertaya, Christopher B. Marshall, Yeliz Celik, Peter L. Davies, Ido Braslavsky, Biophysical Journal, 2008, 95(1)333-342. related news

"Interactions of β-helical Antifreeze Protein Mutants with Ice", Maya Bar, Yeliz Celik, Deborah Fass, Ido Braslavsky, Crystal Growth  &  Design, 2008. 8(8)2954-2963   pdf

"Single Molecule DNA Sequencing of a Viral Genome", Timothy D. Harris, Phillip R. Buzby, Hazen Babcock, Eric Beer, Jayson Bowers, Ido Braslavsky, Marie Causey, Jennifer Colonell, James DiMeo, J. William Efcavitch, Eldar Giladi, Jaime Gill, John Healy, Mirna Jarosz, Dan Lapen, Keith Moulton, Stephen R. Quake, Kathleen Steinmann, Edward Thayer, Anastasia Tyurina, Rebecca Ward, Howard Weiss, Zheng Xie, Science, April 4, 2008, Vol. 320 pp. 106-109

"Growth-melt asymmetry in ice crystals under the influence of spruce budworm antifreeze protein", Natalya Pertaya, Yeliz Celik, Carlos L. DiPrinzio, J. S. Wettlaufer,Peter L. Davies, Ido Braslavsky.  J. Phys.: Condens. Matter 19 (2007) 412101 (12pp) ,  pdf , related movies

"Fluorescence microscopy evidence for quasi-permanent attachment of antifreeze proteins to ice surfaces", Natalya Pertaya, Christopher B. Marshall, Carlos L. DiPrinzio, Larry Wilen, Erik S. Thomson, J. S. Wettlaufer, Peter L. Davies, Ido Braslavsky,  Biophysical Journal, 92(10)3663, 2007.  pdf

Book Chapter:  "Single Molecule Fluorescence Microscopy and its Applications to Single Molecule Sequencing by Cyclic Synthesis", B. Hebert and I. Braslavsky, in Book titled: "New High Throughput Technologies for DNA Sequencing and Genomics", Edited by Keith Mitchelson, ISBN-13: 978-0-444-52223-8, Elsevier

"Sequence information can be obtained from single DNA molecules"
Ido Braslavsky, Benedict Hebert, Emil Kartalov, and Stephen R. Quake, PNAS, 100(2003)3960 pdf, F1000, Physics News Update.

"Objective-Type Dark Field Illumination for Scattering from Microbeads",
Ido Braslavsky, Roee Amit, B. M. Jaffar Ali, Opher Gileadi,  Amos Oppenheim, and Joel Stavans, Applied Optics, 40 (2001) 5650 pdf

"Compaction of Single DNA Molecules Induced by Binding of Integration Host Factor (IHF)",
B. M. Jaffar Ali, Roee Amit, Ido Braslavsky,Amos B.Oppenheim, Opher Gileadi, and Joel Stavans, PNAS 98 (2001) 10658-10663 pdf

"The Double-Pyramid Structure of Dendritic Ice Growing From Supercooled Water"
I. Braslavsky and S.G. Lipson, Journal of Crystal Growth 198-199 (1999) 56. pdf

."Imaging fields around growing crystals", by A. G. Notcovich, I. Braslavsky, S. G. Lipson,
Journal of Crystal Growth 198-199 (1999) 10. pdf

After image, Time sequence growth of an ice dendrite, OPN, Optics & Photonics News, May 1998 Vol. 9 No. 5, p.88.

"Interferometric Measurement of the Temperature Field in The Vicinity of Ice Crystals Growing From Supercooled Water" by I. Braslavsky and S.G. Lipson, Physica A 249 (1998) 190-195.  pdf

"Interferometric Tomography Measurement of the Temperature Field in the Vicinity of a Dendritic Crystal Growing from a supercooled Melt" I. Braslavsky and S.G. Lipson, Transactions of Optical methods and data processing in heat and fluid flow, IMECHE, London 1998, p. 423-432. pdf

"Electrofreezing Effect and Nucleation of Ice Crystals in Free Growth Experiments"
I. Braslavsky and S.G. Lipson, Applied Physics Letter 72 (1998) 264-266.  pdf

Patents

Patent US 7,297,518 B2, "Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension",
Stephen Quake,  Ido Braslavsky, Benedict Hebert, and Emil Kartalov, Publication date: Nov20, 2007


Abstracts

"Why are hyperactive ice-binding-proteins so active?", Ido Braslavsky,  Yeliz Celik,  Natalya Pertaya,  Young Eun Choi, Maya Bar, Peter L. Davies,  APS March meeting 2008 Abstract

"Growth-melt asymmetry in ice crystals under the influence of spruce budworm antifreeze protein", Ido Braslavsky, Natalya Pertaya, Carlos L. DiPrinzio, J. S. Wettlaufer, Peter L. Davies. .Biophysical Society 2007, Abstract

"A study on the interactions of antifreeze proteins with ice crystals using microfluidics", Yeliz Celik, Natalya Pertaya, Larry Wilen, Alex Groissman, J. S. Wettlaufer, Peter L. Davies, Ido Braslavsky. Biophysical Society 2007, Abstract

"Basal Plane Affinity of an Insect Antifreeze Protein",  N. Pertaya, S.Y. Gauthier, P.L. Davies, I. Braslavsky , APS March meeting 2007 Abstract

"Fluorescence microscopy studies of ice surface - antifreeze proteins interactions", Pertaya N., Marshall C.B., DiPrinzio C.L., Wilen L., Thomson E., Wettlaufer J.S., Davies P.L.,Braslavsky I., P 109 116-P037, poster in 11th International Conference on the Physics and Chemistry of Ice, PCI 2006, Bremerhaven, Germany, July 23–28, 2006

"Evidence to DNA Oxidation in single molecule experiments", Douglas wylie and  Ido Braslavsky, Master Thesis,  Frontiers in Chemical Biology: Single Molecules, Cambridge, UK, 3/2006.

"Single Molecule DNA sequencing by Cyclic synthesis", Braslavsky, Harris, Buzby, Babcock, Beer,Causey, Colonell, DiMeo, Efcavitch, Gill, Healy, Ickes ,Jarosz, Karsh, Lapen, Steinmann,Ulmer,Weber, Weiss, Xie.  Frontiers in Chemical Biology: Single Molecules, Cambridge, UK, 3/2006.

"Antifreeze Protein Binds Irreversibly to Ice",  Braslavsky,  Pertaya,  Di Prinzio, Thomson, Wilen, Wettlaufer, Marshall,  and Davies ,  APS March meeting, 2006

"Fluorescence microscopy studies of the hyperactive antifreeze protein from an insect" Pertaya,  Di Prinzio, Thomson, Wilen, Wettlaufer,Marshall,  Davies and Braslavsky,  APS March meeting, 2006

"Fluorescence and confocal microscopy studies of ice surface--antifreeze protein interactions" Natalya Pertaya, Carlos L. Di Prinzio, Erik Thomson, Larry Wilen, John Wettlaufer, Peter L. Davies, Ido Braslavsky, APS, March meeting 2005.

"Fluorescence microscopy studies of ice surface--antifreeze protein interactions",
Natalya Pertaya, Carlos L. Di Prinzio, Erik Thomson, Larry Wilen, John Wettlaufer, Peter L. Davies, Ido Braslavsky, BIOPHYSICAL JOURNAL 88 (1): 81A-82A Part 2 Suppl. S JAN 2005 Abstract, Biophysics 2005

"Single Molecule Measurements of DNA Polymerase Activity:A Step Towards Single Molecule Sequencing", Ido Braslavsky, Emil Kartalov,Benedict Hebert, Stephen R. Quake, Biophysical Journal, 82(2002)507A

"Optical Measurements of the Temperature Field in the Vicinity of Growing Crystal using Interference Tomography", by Henry Fenichel, I. Braslavsky, and S. G. Lipson, Bulletin of the American Physical Society, Vol. 44, No. 1, Part ii, (1999) 1573.


Funding
NSF - National Science Faundation.
BNNT - The Biomimetic Nanoscience and Nanoscale Technology initiative at Ohio University
NQPI -  Nanoscale and Quantum Phenomena Institute



Awards

2000-2001  CMB fellowship, Caltech interdisciplinary program funded by Burroughs Wellcome Fund.
2000          Lester Deutsch, Technion-Caltech fellowship.
1999-1998 The Sir Charles Clore Postdoctoral Fellowship at the Weizmann Institute of Science. 1997-1992 Successive Technion graduate school scholarships including excellence scholarship 1992.
1992          Technion Physics' Dean honors
1991          Participation in distinguished students summer in physics, sponsored by the
                 Amos De-Shalit foundation, Weizmann institute of science.
1991          Technion Physics' Dean honors.
1990          Technion President's honors.
 
  
Teaching

Honor Tutorial teaching, 299T
Biophysics Lab development with Dr David Tees: Optical Tweezers, fluorescence microscopy and Microfluidics
Optics
Modern Physics(Phys 254)
Mechanics(Phys 251)
Introduction to Hydrostatic, Waves, Thermodynamics. and Electricity (Phys 252)
Lab Coordinator, Mechanics and Electricity
Undergraduat Honor Thesis
Biophysics Seminar coordinator

Presentations

Invited Lectures and Colloquium:

 “Antifreeze Protein Binding Dynamics at Ice Surfaces”  in the session on Organic and Biological Crystallization at the 16th International Conference on Crystal Growth, Beijing, China, from August 8 to 13, 2010.

Applied Single-Molecule Techniques, Workshop, Biophysical Society, San Francisco, Feb 2010.

Ice & Water in the Universe: from Astrobiology to Terrestrial Bodies,  Stockholm, Sweeden, 15-26 September 2008.

Innovative Approaches to DNA Sequencing, New York Academy of Science, New York, Nov 2007

NanoTx 07: Antifreeze proteins and their applications , Dallas, TX, Oct 2007

"Fluorescence Microscopy and Microfluidic Techniques for studyng interactions between antifreeze proteins and ice surfaces", ACS, Antifreeze Proteins: A Memorial Symposium for Robert Feeney , Boston,  Aug 2007

 "Investigation of the Interactions Between Antifreeze Proteins and Ice Surfaces Using Fluorescence Microscopy and Microfluidic Techniques", Kenyon college Physics Colloquium, Gambier, OH, December 2006

"Single molecule DNA sequencing",Optics in the Southeast 2005 Workshop on Biophotonics, Atlanta, GA, 10/2005

"Single molecule DNA sequencing by cyclic synthesis" ABRF 2005 Biomolecular Technologies: Discovery to Hypothesis, Savannah,  February 5 – 8,2005.

"Single molecule detection and manipulation",Weizmann-wide workshop on physics in biology, 17 January 1999  

"The Double Pyramid Structure of Ice", Seminar, Physical Chemistry, Hebrew University 12/97.

Outreach:
Snow day, Athens Public Library, January 24, 2008.
Rainbow day, Athen Public Library, April 2, 2009.


Participation in:

Society of Low Temperature Biology, Hannover, Germany, 9/2009
Ice Binding Proteins Workshop, Kingston, Ontario, Canada, 8/2009
Cryobiology 2009, Sapporo, Japan, 7/2009
APS, Pittsburg, Pennsylvania, 3/2009
Biophysical Society, 53th annual meeting, Boston 2/2009
Biomineralization, GRC, New Londen, NH, 8/2008
Ice Binding Proteins Workshop, Kingston, Ontario, Canada,8/2008
Cryobiology 2008, Charlotte, NC, 7/2008
NSS5/SPS2, Athens, OH, 7/2008
APS, New Orleans, Louisiana, 3/2008
ACS, Boston, MA, Aug 2007
NanoSummit, Akron Ohio, 4/2007
APS, Denver Colorado, press conference, 3/2007
Ohio Nano Summit, Columbus, Ohio, 4/2006
Frontiers in Chemical Biology: Single Molecules, Cambridge, UK, 3/2006.
APS, Baltimore, MD,   3/2006.
GRC on ThinFilm & Crystal Growth Mechanisms, MA,  6/2005, Hot topic presentation.
APS, Los Angeles, CA 3/2005.
Biophysical Society, 49th annual meeting, Los Angeles, CA 2/2005
Biophysical Society, 48th annual meeting, Baltimore, 2/2004
DNA Sequencing Technologies and Computation, RECOMB 2003, Stanford University, CA,  5/2003
Symposium on Stress Proteins, From Heat Shock to Antifreeze, Bodega, CA, 3/2003
Biomineralization , Gordon Conference, NH, 8/2002
Nanoscale/Molecular Mechanics, Maui, Hawaii, 5/2002
Biophysical Society, 46th annual meeting, San Francisco, California, 2/2002
SPIE, Biomedical Optics, San Jose, California,1/2002
Mathematics And Molecular Biology VII: Modeling Across the Scales: Atoms to Organisms, Santa Fe, New Mexico 1/2002
APS, Seattle 3/2001.
Single molecule biophysics, International EMBO Workshop, Tours, France 7/1999
The Twelfth International Conference on Crystal Growth, 7/1998 Jerusalem, Israel
Optical Methods and Data Processing in Heat and Fluid Flow, London, England 4/1998    (ppt file 2.2Mb)
NATO Advanced Study Institute on Ice Physics in the Natural and Endangered Environment, Acquafredda di Marate, Italy 9/1997
IPS, Ben-Gurion University, Israel 4/1997
Physics of Complex Systems, Bar-Ilan University, Israel 3/1997
Dynamic Days Programs (Minerva Center) Technion, Israel 10/1995
German-Israeli Symposium on Optical Signal and Image Processing, Herzliya, Israel, 6/1994

Seminars at universities and institutions:

2009 Biophysics, Michigan University, Ann Arbor, MI, USA
2009 AIST, Sapporo, Japan
2008 Physics, Technion, Israel
2008 Physics, Bar Ilan, Israel
2008 Biochemistry Food Science and Nutrition, Hebrew University of Jerusalem, Rehovot campus, Israel
2008 Bioengineering, Hebrew University of Jerusalem, Jerusalem, Israel
2008 Physics, Ben Gurion University, Israel
2008 Chemistry, Tel Aviv University, Israel
2007 Soft Matter & Biomaterials  and Structural Biology, Weizmann institute of Science, Rehovot, Israel.
2006 Chemistry and Biochemistry, Ohio University, OH
2006 NQPI retreat, Ohio university
2005 Bioengineering, Stanford University, CA
2005 Biotechnology and Food Eng, Israel Institute of Technology
2005 Mathematics, Ohio University, OH
2005 Physics, Ohio-State University, OH
2004 Applied Physics, Harvard, MA
2004 Physics, Cincinnati University, OH
2003 Physics, Brown University, RI
2003 Biotechnology and Food Eng, Israel Institute of Technology
2003 TuDelft, Delft, Netherlands
2003 Intel, Santa Clara, CA
2003 Physics, Riverside, CA
2003 Physics, Santa Barbara, CA
2003 Physics, Austin, Texas
2003 Physics, Athens, Ohio
2003 Physics, Wayne State, MI
2002 Chemistry, Tel Aviv University, Israel
2002 Chemistry, Technion, Israel
2002 Physics, Irvine, California
2001 Material and Interfaces, Weizmann Institute of Science.
2001 Physics department, Israel Institute of Technology.
2001 Chemical Engineering, Israel Institute of Technology.
2001 Physics department, Jerusalem.
2001 Electrical  Engineering, Israel Institute of Technology.
2001 Chemical engineering department, Ben Gurion University.
2001 Physics department, Tel Aviv.
 

Professional Activities

Session Chair:
2006 APS March Meeting Session D9: Methods in Nanobiotechnology

Member of:
Biophysical Society
American Physical Society
Cryobiology Society

Research Interests

Experimental complex systems physics, Biophysics, Applied optics. 
Anti-freeze proteins:  Hyperactive Ice binding proteins, Investigation with fluorescence microscopy and microfluidic devices.  
Ice physics,  Electrofreezing, The double pyramid structure of ice,  growth-melt asymmetry, 
Refractive index of water, Crystal growth. 
Temperature controlled Microfluidics
Single molecule detection and manipulation:  DNA–Protein interactions, Single molecule DNA sequencing, 
DNA Oxidation at the single molecule level.
Optics:  Interferometric measurements, Tomographic interferometry, Confocal fluorescent microscopy, Optical tweezers, Evanescent illumination, Darkfield microscopy, Wavefront Shaping.

 
Students and Postdocs

Yeliz Celik, Phd Student,
             Ohio University creative fair 1st place 2007,
            Sigma Xi award 2008,  
            NQPI/BNNT/CMSS 1st place poster 2008
Yangzhong Qin, Phd Student
Di Xu,  Master Student, 2009
Vincent Roberts, Undergraduate, 2009

Visiting Scienticts
1-7/2008  Liu Junjie
4/2007  Maya Bar
Short visits:
2009 Laurie Graham
2006 Alexander Heiss

Alumni

Paul Ingram, Undergraduate, Honor thesis, poster on "Optical tweezers in undergradute lab"
Young Eun Choi, Master Student, 2006 - 2007, Thesis
Natalya Pertaya, Postdoc, 2004-2007
Douglas Wylie,  Master Student, 2004-2006,  Thesis
John Peters, short term postdoc 2006.
Carlos De Prinzio, postdoc 2005

Updated: March 2010   עדו ברסלבסקי
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