"Spatial evolutionary game of cancer: Applying Physics to Cancer"
Cancer is a complex condition with strong ecological elements, often consisting of stromal cells as well as cancer cells. Stromal cells provide protection from drug-induced apoptosis in cancer via secreting growth signals and further mediate cancer cell growth and survival under treatment. I'll talk about a microfluidic ecology which mimics the bone marrow ecology under chemotherapy, including extracellular matrix and stromal cells, drug gradients, and weakly connected micro-habitats, to visualize the dynamics of multiple myeloma and stromal cell interactions and the emergence of resistance. We model the observed spatial dynamics of emergent resistance using spatial evolutionary game theory, with (i) fitness as a function of population composition and drug concentration, and (ii) spatial coupling via diffusive migration and fitness-driven migration of the cells.